protein

UNC5B Protein, Rat (HEK293, Fc)

HY-P76120

5 μg;10 μg;50 μg

35;60;170 USD

UNC5B Protein, Rat (HEK293, Fc)

proteins

HEK293

5 μg;10 μg;50 μg

35;60;170 USD

UNC5B is a netrin-1-dependent receptor. It negatively regulates vascular branching during angiogenesis. In addition, UNC5B protects myelin and partially alleviates injury-induced neuropathic pain (NP). UNC5B is involved in the guidance of axons and the positive regulation of exogenous apoptosis signaling pathways without binding to netrin-1. UNC5B Protein, Rat (HEK293, Fc) is the recombinant rat-derived UNC5B protein, expressed by HEK293 , with C-hFc labeled tag.

Rat

UNC5B promotes autophagic flux in Schwann cells (SCs) through phosphorylation of AMPK and ULK1, depending on its ligand netrin-1, protecting myelin and partially preventing injury-induced neuropathic pain (NP) [1] . UNC5B also plays a role in axon guidance and positively regulates exogenous apoptosis signaling pathways without binding to netrin-1 [2] . The activation of UNC5B inhibits sprouting angiogenesis, making it a potential anti-angiogenic target [3] .

Netrin receptor UNC5B; p53RDL1; UNC5B; P53RDL1; UNC5H2

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.