protein

Fibrillin-1/Asprosin Protein, Human (HEK293, His)

HY-P7612

5 μg;10 μg;50 μg;100 μg;250 μg;500 μg;1 mg

85;135;350;525;850;1250;1900 USD

Fibrillin-1/Asprosin Protein, Human (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg;250 μg;500 μg;1 mg

85;135;350;525;850;1250;1900 USD

Fibrillin-1 and Asprosin are two proteins generated from the same precursor protein, which is encoded by the Fibrillin 1 gene, through proteolytic cleavage. Fibrillin-1 protein, a member of the fibrillin family, is a crucial structural protein in the formation of microfibrils in the extracellular matrix, maintaining tissue homeostasis and cell adhesion, regulating the availability of growth factors, and inhibiting osteoclastogenesis. In contrast, Asprosin is a hormone primarily secreted by white adipose tissue and is involved in regulating glucose metabolism within the body. Fibrillin-1/Asprosin protein, Human (HEK293, His) is a recombinant protein expressed in HEK293 cells with an N-terminal His tag, comprising a full length of 140 amino acids (S2732-H2871) [1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [11] .

Human

Fibrillin-1 is a key structural protein in the formation of extracellular matrix microfibrils. It plays a critical role in maintaining the structural integrity and functional stability of connective tissues, not only providing physical support but also participating in the regulation of tissue homeostasis and bone metabolism through interactions with various growth factors, integrins, and heparin. 1. Physical Structural Support: (1) In tissues such as the lung, blood vessels, and skin, Fibrillin-1 supports the formation of elastic fibers [1] . (2) In tissues lacking elastin, such as the ciliary zonule, tendon, cornea, and glomerulus, Fibrillin-1 provides structural support [1] . 2. Homeostasis Regulation and Metabolic Control: (1) Fibrillin-1 maintains tissue structural stability through specific interactions with growth factors (such as bone morphogenetic proteins ( BMPs ), growth and differentiation factors ( GDFs ), latent transforming growth factor beta-binding proteins ( LTBPs )), cell surface integrins, and other extracellular matrix proteins and proteoglycan components [1] . (2) Fibrillin-1 inhibits osteoclastogenesis by binding to the osteoclast differentiation factor TNFSF11 and suppressing the TNFSF11-mediated nuclear translocation and activation of the transcription factor NFATC1 , thereby influencing bone metabolism [2] . Fibrillin-1 mediates cell adhesion by binding to cell surface receptors integrins ITGAV and ITGA5 [3] [4] . It can also bind heparin , ensuring the proper assembly of microfibrils [5] . Asprosin is a hormone secreted by white adipose tissue that plays a crucial role in regulating energy balance in the body, particularly in maintaining blood glucose levels during fasting. Asprosin acts on the liver during fasting by binding to the olfactory receptor OR4M1 on hepatocytes, activating protein kinase A ( PKA ), and triggering the rapid release of glucose into the bloodstream. Asprosin also promotes rapid glucose release by activating the G protein-cAMP-PKA pathway [6] [7] [8] [9] .

rHuAsprosin, His; Fibrillin-1; FBN1; Asprosin; FBN

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS or 20 mM PB, 150 mM NaCl, pH 7.4 or PBS, pH 7.4, 8% trehalose.

Room temperature in continental US; may vary elsewhere.