protein

TPM4 Protein, Human (HEK293, His)

HY-P76111

5 μg;10 μg;50 μg

55;95;260 USD

TPM4 Protein, Human (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg

55;95;260 USD

The TPM4 protein binds actin filaments in muscle and non-muscle cells and critically regulates calcium-dependent muscle contraction with the help of the vertebrate troponin complex. In smooth muscle cells, TPM4 interacts with caldesmon and contributes to contraction regulation. TPM4 Protein, Human (HEK293, His) is the recombinant human-derived TPM4 protein, expressed by HEK293 , with N-His, N-6*His labeled tag. The total length of TPM4 Protein, Human (HEK293, His) is 247 a.a., with molecular weight of 35-40 kDa.

Human

TPM4 protein exhibits binding specificity to actin filaments in both muscle and non-muscle cells, playing a pivotal role, particularly in conjunction with the troponin complex, in the calcium-dependent regulation of striated muscle contraction in vertebrates. In smooth muscle cells, TPM4 contributes to the regulation of contraction through interaction with caldesmon. In non-muscle cells, TPM4 is implicated in stabilizing actin filaments within the cytoskeleton. Additionally, TPM4 has a calcium-binding capacity, as demonstrated in studies. It forms homodimers and heterodimers, the latter composed of an alpha chain (TPM1, TPM3, or TPM4) and a beta chain (TPM2), showcasing its versatility in molecular configurations. The multifaceted interactions of TPM4 underscore its essential roles in both muscle contraction and cytoskeletal dynamics across diverse cellular contexts.

Tropomyosin alpha-4 chain; TM30p1; Tropomyosin-4; TPM4

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.