protein

PPM1A Protein, Mouse (His)

HY-P75979

5 μg;10 μg;50 μg;100 μg

35;60;170;290 USD

PPM1A Protein, Mouse (His)

proteins

E. coli

5 μg;10 μg;50 μg;100 μg

35;60;170;290 USD

PPM1A is a multifunctional enzyme whose enzymatic activity exhibits broad specificity. It acts as a negative regulator of TGF-β signaling by dephosphorylating SMAD2 and SMAD3, leading to their dissociation from SMAD4, nuclear export of SMAD, and termination of TGF-β-mediated signaling. PPM1A Protein, Mouse (His) is the recombinant mouse-derived PPM1A protein, expressed by E. coli , with C-His labeled tag.

Mouse

Protein Phosphatase, Mg2+/Mn2+ Dependent 1A (PPM1A) is an enzyme characterized by its broad specificity. It functions as a negative regulator of TGF-beta signaling by dephosphorylating SMAD2 and SMAD3, leading to their dissociation from SMAD4 and subsequent nuclear export. This enzymatic activity ultimately terminates the TGF-beta-mediated signaling pathway. Additionally, PPM1A dephosphorylates PRKAA1 and PRKAA2, contributing to the regulation of cellular processes associated with AMP-activated protein kinase. Furthermore, PPM1A plays a crucial role in the termination of TNF-alpha-mediated NF-kappa-B activation by dephosphorylating and inactivating IKBKB/IKKB. The diverse substrate specificity of PPM1A underscores its importance in modulating key signaling pathways, highlighting its regulatory functions in cellular responses to TGF-beta and TNF-alpha signaling (

Protein Phosphatase 1A; Protein Phosphatase 2C Isoform Alpha; PP2C-Alpha; PPPM1A

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.