protein

NETO1 Protein, Human (HEK293, His)

HY-P75937

5 μg;10 μg;50 μg;100 μg

45;75;200;340 USD

NETO1 Protein, Human (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

45;75;200;340 USD

The NETO1 protein complexly maintains neuronal circuits as an auxiliary subunit of NMDARs, which is critical for the abundance of GRIN2A-containing NMDARs in the postsynaptic density. It regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, particularly in spatial learning and memory. NETO1 Protein, Human (HEK293, His) is the recombinant human-derived NETO1 protein, expressed by HEK293 , with C-His labeled tag.

Human

The NETO1 Protein is intricately involved in the development and maintenance of neuronal circuitry. Serving as an accessory subunit of the neuronal N-methyl-D-aspartate receptor (NMDAR), NETO1 plays a critical role in maintaining the abundance of NMDARs containing GRIN2A in the postsynaptic density. Furthermore, NETO1 functions as a regulator of long-term NMDA receptor-dependent synaptic plasticity and cognition, particularly in the context of spatial learning and memory. The protein's interactions extend to the PLZ domains of DLG2, DLG3, and DLG4 through its C-terminal TRV domain, highlighting its involvement in synaptic signaling complexes. Additionally, NETO1 interacts with GRIN2A and GRIN2B via its CUB domains, indicating its role in modulating the composition and function of NMDARs in neuronal synapses.

Neuropilin and tolloid-like protein 1; NETO1; BTCL1

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.