protein

LSM3 Protein, Human (His)

HY-P75915

5 μg;10 μg;50 μg

35;60;170 USD

LSM3 Protein, Human (His)

proteins

E. coli

5 μg;10 μg;50 μg

35;60;170 USD

The LSM3 protein plays a crucial role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP complex involved in spliceosome assembly and as part of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex (including LSM3) specifically binds to the 3'-end U strand of U6 snRNA. LSM3 Protein, Human (His) is the recombinant human-derived LSM3 protein, expressed by E. coli , with N-His labeled tag.

Human

LSM3 protein serves a pivotal role in pre-mRNA splicing as a crucial component of the U4/U6-U5 tri-snRNP complex, which participates in spliceosome assembly and the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex, in which LSM3 is a constituent, specifically binds to the 3'-terminal U-tract of U6 snRNA. This intricate machinery, composed of various snRNPs and associated proteins, including LSM3, LSM2, LSM4, LSM5, LSM6, LSM7, and LSM8, forms a ring-shaped subcomplex within the U4/U6-U5 tri-snRNP complex. These interactions emphasize LSM3's essential contribution to the complex orchestration of spliceosome assembly and pre-mRNA processing.

U6 snRNA-associated Sm-like protein LSm3; LSM3; MDS017

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.