protein

KIAA0101 Protein, Human (His)

HY-P75900

5 μg;10 μg;50 μg;100 μg

70;110;290;465 USD

KIAA0101 Protein, Human (His)

proteins

E. coli

5 μg;10 μg;50 μg;100 μg

70;110;290;465 USD

The KIAA0101 protein is a PCNA-binding regulator that plays a key role in DNA repair during replication. After DNA damage, it disrupts its interaction with PCNA and promotes the binding between monoubiquitinated PCNA and DNA polymerase eta (POLH). KIAA0101 Protein, Human (His) is the recombinant human-derived KIAA0101 protein, expressed by E. coli , with N-His labeled tag. The total length of KIAA0101 Protein, Human (His) is 111 a.a., with molecular weight of ~17 kDa.

Human

KIAA0101 Protein, a PCNA-binding protein, plays a pivotal role as a DNA repair regulator during DNA replication. Upon DNA damage, its interaction with PCNA is disrupted, promoting the association between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes. This interaction facilitates the bypass of replication-fork-blocking lesions, ensuring the continuity of DNA replication under challenging conditions. Beyond its involvement in DNA repair processes, KIAA0101 also functions as a regulator of centrosome number. The protein interacts with PCNA, particularly when monoubiquitinated at Lys-15 and Lys-24, and additionally forms associations with isoform 2/p33ING1b of ING1 and BRCA1, suggesting its participation in diverse cellular pathways.

PCNA-associated factor; OEATC-1; PAF15; p15PAF; PCLAF; KIAA0101; NS5ATP9; PAF

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.