protein

JTB Protein, Human (HEK293, Fc)

HY-P75896

5 μg;10 μg;50 μg

40;70;200 USD

JTB Protein, Human (HEK293, Fc)

proteins

HEK293

5 μg;10 μg;50 μg

40;70;200 USD

JTB proteins are critical for normal cytokinesis progression, regulate cell proliferation, and may serve as components of the chromosomal passenger complex (CPC) during mitosis. It interacts with key CPC components, affects AURKB activity, and exhibits anti-apoptotic properties, inhibiting TGFB1-induced apoptosis. JTB Protein, Human (HEK293, Fc) is the recombinant human-derived JTB protein, expressed by HEK293 , with C-mFc labeled tag. The total length of JTB Protein, Human (HEK293, Fc) is 75 a.a., with molecular weight of ~38 kDa.

Human

JTB protein is indispensable for the normal progression of cytokinesis during mitosis and plays a crucial role in regulating cell proliferation. It is implicated as a potential component of the chromosomal passenger complex (CPC), a pivotal regulator of mitosis with essential functions at the centromere. The CPC complex is instrumental in ensuring accurate chromosome alignment and segregation, as well as participating in chromatin-induced microtubule stabilization and spindle assembly. JTB interacts with key components of the CPC, including AURKA, AURKB, BIRC5, and INCENP, potentially influencing AURKB activity. Moreover, JTB exhibits anti-apoptotic properties, inhibiting apoptosis induced by TGFB1, and its overexpression is associated with mitochondrial changes, leading to mitochondrial swelling and reduced membrane potential. These multifaceted roles highlight JTB's involvement in intricate cellular processes crucial for mitotic fidelity and cell survival.

Jumping translocation breakpoint protein; Prostate androgen-regulated protein; JTB; HSPC222

Greater than 90% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.