protein

JAML/AMICA Protein, Human (HEK293, His)

HY-P75895

5 μg;10 μg;50 μg

48;82;230 USD

JAML/AMICA Protein, Human (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg

48;82;230 USD

JAML is a leukocyte plasma membrane transmembrane protein that critically regulates cell migration and activation by interacting with CXADR on neighboring cells. This interaction activates γ-δ T cells and induces downstream signaling through PI3 kinase and MAP kinase. JAML/AMICA Protein, Human (HEK293, His) is the recombinant human-derived JAML/AMICA protein, expressed by HEK293 , with C-His, C-6*His labeled tag.

Human

JAML, a transmembrane protein residing on the plasma membrane of leukocytes, serves as a crucial regulator of cell migration and activation by engaging with CXADR, a receptor located on adjacent epithelial and endothelial cells. This interaction, pivotal for the activation of gamma-delta T-cells, a subset involved in tissue homeostasis and repair, induces downstream signaling events in response to epithelial CXADR-binding. JAML-mediated signaling, facilitated by PI3-kinase and MAP kinases, leads to T-cell proliferation and the production of cytokines and growth factors, fostering tissue repair. Additionally, JAML plays a pivotal role in controlling leukocyte transmigration within epithelial and endothelial tissues through adhesive interactions with CXADR. In its homodimeric form, JAML actively participates in leukocyte-endothelial cell adhesion, highlighting its multifaceted role in orchestrating immune responses and tissue repair processes. Furthermore, JAML's interaction with integrins ITGA4 and ITGB1 suggests a regulatory mechanism for leukocyte-endothelial cell adhesion by modulating JAML homodimerization.

Junctional adhesion molecule-like; JAML; AMICA1; CREA7-1

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 or 20 mM PB, 150 mM NaCl, pH 7.4.

Room temperature in continental US; may vary elsewhere.