protein

IL-18R alpha Protein, Human (HEK293, Fc)

HY-P75842

5 μg;10 μg;50 μg;100 μg

49;84;235;400 USD

IL-18R alpha Protein, Human (HEK293, Fc)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

49;84;235;400 USD

IL-18R alpha (interleukin-18 receptor alpha) is an interleukin receptor of the immunoglobulin superfamily. IL-18 forms a signalling complex with the IL-18 receptor α (Rα) and β (Rβ) chains at the plasma membrane, which induces multiple inflammatory cytokines [1] . IL-18R complex recruits the IL-1R- activating kinase and TNF- associated factor 6, which phosphorylates nuclear factor kβ- inducing kinase, with subsequent activation of nuclear factor kβ [2] . IL-18R alpha inhibits the production of IFN-γ stimulated with the combination of rhIL-2 and rhIL-18 [3] . IL-18R alpha Protein, Human (HEK293, Fc) is a recombinant protein with a Fc label that consists of 329 amino acids (M1-R329) and is produced by HEK293 cells.

Human

IL-18R alpha is expressed on CD4 + and CD8 + T cells but not expressed on naive T cells [4] . The amino acid sequence of human IL-18R alpha protein has low homology for mouse IL-18R alpha protein. IL-18R alpha is the receptor of IL-18. IL-18 is extracellularly secreted and binds IL-18 receptor α (Rα) as well as IL-18 receptor β (Rβ) at the immunocyte plasma membrane in a stepwise manner. IL-18/IL-18Rα/IL-18Rβ ternary complex formation juxtaposes the intracellular Toll-Interleukin-1 receptor domains of IL-18Rα and IL-18Rβ. Then, the adaptor molecule myeloid differentiation factor 88 (MyD88) is recruited presumably with the aid of TRAM. MyD88 further interacts with IL-1 receptor associating kinase (IRAK) 4 and IRAK1/2 to form the large molecular assembly referred to as Myddosome, which subsequently activates IKK via TRAF6. Finally, the signal activates the NF-κB and mitogen-activated protein kinase pathways7, which upregulate the expression of various inflammatory cytokines [1] . IL-18R alpha binds to IL-18 and IL-18 receptor β forms a signalling complex induces the expression of various inflammatory cytokines [1] . IL-18R alpha inhibits the production of IFN-γ stimulated with the combination of rhIL-2 and rhIL-18 [3] .

Interleukin-18 receptor 1; IL-18R1; CDw218a; IL-1Rrp; IL-18R-alpha; CD218a; IL18R1

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

Room temperature in continental US; may vary elsewhere.