protein

IL-17B Protein, Mouse (sf9, Fc)

HY-P75835

50 μg

300 USD

IL-17B Protein, Mouse (sf9, Fc)

proteins

Sf9 insect cells

50 μg

300 USD

IL-17B is a proinflammatory cytokine and stimulates the release of tumour necrosis factor alpha (TNFα) and IL-1β. IL-17B plays an important role in cancer progression, angiogenesis, and inflammatory arthritis [1] [2] . IL-17B Protein, Mouse (sf9, Fc) is a recombinant mouse IL-17B protein with hFc tag at the C-terminus and is expressed in Sf9 insect cells. It consists of 180 amino acids (M1-F180).

Mouse

Interleukin-17B (IL-17B) belongs to the IL-17 cytokine family and is a proinflammatory cytokine. IL-17B is expressed in adult pancreas, small intestine, stomach, spinal cord and testis. Murine IL-17B mRNA was detected in the whole mouse embryo [1] [3] . The mouse IL-17B shares 88.33% amino acid sequence identity with human. IL-17B is secreted as a non-covalent dimer glycoprotein. IL-17B shares about 27% amino acid identity with IL-17A and stimulates the release of tumour necrosis factor alpha (TNFα) and IL-1β in the THP-1 monocytic cell line. The receptor of IL-17B is IL-17RB, which belongs to the IL-17 receptor family. IL-17B shares IL-17RB with IL-17E. IL-17B inhibits IL-17E binding to IL-17RA/IL-17RB complexes, exhibits protumor roles and IL-17E antitumor activities [1] [2] . IL-17B plays an important role in cancer progression, angiogenesis, and inflammatory arthritis [1] .

Interleukin-17B; IL-17B; Cytokine Zcyto7; IL-20; NIRF; ZCYTO7

Greater than 90% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of 100 mM Glycine, 10 mM NaCl, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

Room temperature in continental US; may vary elsewhere.