protein

IFI30 Protein, Human (HEK293, His)

HY-P75820

5 μg;10 μg;50 μg;100 μg

52;88;247;420 USD

IFI30 Protein, Human (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

52;88;247;420 USD

IFI30 is a lysosomal thiol reductase that plays a critical role in reducing protein disulfide bonds in the lysosomal environment. This enzymatic activity is critical for complete unfolding of proteins for lysosomal degradation. IFI30 Protein, Human (HEK293, His) is the recombinant human-derived IFI30 protein, expressed by HEK293 , with C-His labeled tag. The total length of IFI30 Protein, Human (HEK293, His) is 217 a.a., with molecular weight of 31-34 kDa.

Human

IFI30, a lysosomal thiol reductase, serves as a key player in the reduction of protein disulfide bonds within the lysosomal environment. This enzymatic activity is crucial for the complete unfolding of proteins targeted for lysosomal degradation. Notably, IFI30 plays a pivotal role in antigen processing, specifically contributing to the generation of MHC class II-restricted epitopes from antigens containing disulfide bonds through endocytic reduction. Additionally, IFI30 is implicated in facilitating MHC class I-restricted recognition of exogenous antigens with disulfide bonds by CD8+ T-cells, thus contributing to cross-presentation processes.

Gamma-interferon-inducible lysosomal thiol reductase; Legumaturain; GILT; IP30

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.