protein

FRZB Protein, Human (HEK293, His)

HY-P75780

5 μg;10 μg

60;105 USD

FRZB Protein, Human (HEK293, His)

proteins

HEK293

5 μg;10 μg

60;105 USD

FRZB protein is a soluble Frizzled-related protein (sFRP) that modulates Wnt signaling by directly interacting with Wnt, thereby regulating cell growth and differentiation. FRZB, also known as SFRP3, plays a key role in limb skeletogenesis as a Wnt8 signaling antagonist. FRZB Protein, Human (HEK293, His) is the recombinant human-derived FRZB protein, expressed by HEK293 , with C-His labeled tag.

Human

FRZB, a soluble frizzled-related protein (sFRP), assumes a pivotal role in modulating Wnt signaling through its direct interaction with Wnts, contributing to the regulation of cell growth and differentiation in specific cell types. Particularly, FRZB, also known as SFRP3, plays a crucial part in limb skeletogenesis, functioning as an antagonist of Wnt8 signaling. Its regulatory influence extends to the precise orchestration of chondrocyte maturation and long bone development. In addition to its involvement in Wnt signaling modulation, FRZB engages in molecular interactions, exemplified by its interaction with MYOC, thereby highlighting its diverse functions and importance in cellular processes. The multifaceted regulatory role of FRZB underscores its significance in the intricate landscape of Wnt-mediated pathways and skeletogenesis.

Secreted frizzled-related protein 3; sFRP-3; Frezzled; FrzB-1; FRZB; SFRP3

Greater than 85% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.