protein

EphA7 Protein, Mouse (HEK293, His)

HY-P75746

2 μg;10 μg;50 μg;100 μg;500 μg

35;55;150;260;730 USD

EphA7 Protein, Mouse (HEK293, His)

proteins

HEK293

2 μg;10 μg;50 μg;100 μg;500 μg

35;55;150;260;730 USD

The EphA7 protein is a receptor tyrosine kinase that participates in bidirectional signaling with GPI-anchored ephrin-A ligands (especially EFNA5). It affects brain development by regulating intercellular adhesion and repulsion, contributing to axonal guidance of corticothalamic and retinal axons. EphA7 Protein, Mouse (HEK293, His) is the recombinant mouse-derived EphA7 protein, expressed by HEK293 , with C-His labeled tag. The total length of EphA7 Protein, Mouse (HEK293, His) is 529 a.a., with molecular weight of 68-77 kDa.

Mouse

EphA7 protein, a receptor tyrosine kinase, binds to GPI-anchored ephrin-A ligands on neighboring cells, initiating contact-dependent bidirectional signaling. This receptor is involved in forward signaling, while the ephrin ligand triggers reverse signaling. Among the ephrin-A ligands, EFNA5 specifically interacts with EphA7, regulating brain development by influencing cell-cell adhesion and repulsion. EphA7 also plays a crucial role in axon guidance, ensuring the proper mapping of corticothalamic and retinal axons. Additionally, EphA7 may contribute to brain development through its proapoptotic activity, which depends on caspase (CASP3). Activation of EphA7 can lead to phosphorylation of components of the ERK signaling pathway, including MAP2K1, MAP2K2, MAPK1, and MAPK3. Isoform 4, lacking the kinase domain, may also regulate the adhesive properties of isoform 1.

Ephrin Type-A Receptor 7; mDK-1; EHK-3; EBK

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.