protein

ENPP-2 Protein, Mouse (HEK293, His)

HY-P75733

5 μg;10 μg;50 μg

53;89;250 USD

ENPP-2 Protein, Mouse (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg

53;89;250 USD

The ENPP-2 protein catalyzes the hydrolysis of lysophospholipids (especially lysophosphatidylcholine) to produce the signaling molecule lysophosphatidic acid (LPA).It also acts on sphingosine phosphocholine to produce sphingosine 1-phosphate, which affects cell movement.ENPP-2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived ENPP-2 protein, expressed by HEK293 , with N-His, N-10*His labeled tag.

Mouse

The ENPP-2 Protein hydrolyzes lysophospholipids, specifically lysophosphatidylcholine, to produce the signaling molecule lysophosphatidic acid (LPA) in extracellular fluids. It can also act on sphingosylphosphorylcholine, producing sphingosine-1-phosphate, which modulates cell motility. In addition, ENPP-2 Protein has been shown to hydrolyze bis-pNPP, pNP-TMP, and ATP to varying extents. It is involved in various motility-related processes, including angiogenesis and neurite outgrowth, and acts as an angiogenic factor by stimulating the migration of smooth muscle cells and microtubule formation. ENPP-2 Protein is also implicated in melanoma cell migration, potentially through a pertussis toxin-sensitive G protein. It may play a role in parturition induction, as well as in cell proliferation and adipose tissue development. Furthermore, it is required for LPA production in activated platelets and cleaves sn-1 lysophospholipids to generate sn-1 lysophosphatidic acids containing predominantly 18:2 and 20:4 fatty acids. ENPP-2 Protein exhibits a preference for the sn-1 isomer of 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF).

Ectonucleotide pyrophosphatase/phosphodiesterase family member 2; Autotaxin; LysoPLD; Npps2; Pdnp2

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris, 150 mM NaCl, pH 7.5.

Room temperature in continental US; may vary elsewhere.