protein

EDA2R/XEDAR Protein, Human (HEK293, His)

HY-P75728

2 μg;10 μg;50 μg;100 μg

30;75;180;290 USD

EDA2R/XEDAR Protein, Human (HEK293, His)

proteins

HEK293

2 μg;10 μg;50 μg;100 μg

30;75;180;290 USD

The EDA2R/XEDAR protein acts as a receptor for the EDA isoform A2 (unlike A1) and is critical for activating the NF-kappa-B and JNK pathways. Its activation involves binding to TRAF3 and TRAF6. EDA2R/XEDAR Protein, Human (HEK293, His) is the recombinant human-derived EDA2R/XEDAR protein, expressed by HEK293 , with N-His labeled tag. The total length of EDA2R/XEDAR Protein, Human (HEK293, His) is 138 a.a., with molecular weight of ~23-25 kDa.

Human

EDA2R/XEDAR Protein serves as a receptor specifically for EDA isoform A2, distinguishing it from isoform A1. This receptor plays a crucial role in mediating the activation of the NF-kappa-B and JNK pathways. The activation process appears to be facilitated through the binding of EDA2R/XEDAR to TRAF3 and TRAF6. Additionally, EDA2R/XEDAR forms associations with TRAF1, TRAF3, and TRAF6, indicating its involvement in intricate signaling networks. These interactions highlight the multifaceted role of EDA2R/XEDAR in cellular signaling pathways, emphasizing its potential impact on immune responses and inflammatory processes.

Tumor necrosis factor receptor superfamily member 27; EDA-A2 receptor; EDA2R; TNFRSF27; XEDAR

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.