protein

DNMT2 Protein, Human (sf9, GST)

HY-P75711

100 μg

450 USD

DNMT2 Protein, Human (sf9, GST)

proteins

Sf9 insect cells

100 μg

450 USD

The DNMT2 protein exhibits remarkable specificity by selectively methylating cytosine 38 within the anticodon loop of tRNA (Asp). This site-specific methylation is critical for epigenetic modification of transfer RNA, affecting its structure, stability, and functional interactions. DNMT2 Protein, Human (sf9, GST) is the recombinant human-derived DNMT2 protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of DNMT2 Protein, Human (sf9, GST) is 391 a.a., with molecular weight of ~60 kDa.

Human

DNMT2 protein exhibits remarkable specificity in its enzymatic activity, as it selectively methylates cytosine 38 within the anticodon loop of tRNA(Asp). This site-specific methylation event plays a crucial role in the epigenetic modification of transfer RNA molecules, potentially influencing their structure, stability, and functional interactions. By targeting a specific cytosine residue in the anticodon loop of tRNA(Asp), DNMT2 contributes to the modulation of translational efficiency and fidelity. The enzyme's precision in methylating this particular site underscores its significance in the intricate regulatory mechanisms governing tRNA function, emphasizing the importance of DNMT2 in the epigenetic landscape of cellular processes involving tRNA(Asp).

tRNA (cytosine(38)-C(5))-methyltransferase; M.HsaIIP; PuMet; TRDMT1; DNMT2

Greater than 90% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris, 500 mM NaCl, 0.5 mM GSH, 10% Glycerol, pH 8, 5% Trehalose, 5% Mannitol, 0.01% Tween-80 are added as protectants before lyophilization.

Room temperature in continental US; may vary elsewhere.