protein

DLST Protein, Human (sf9, His)

HY-P75709

5 μg;10 μg;50 μg;100 μg

60;95;265;425 USD

DLST Protein, Human (sf9, His)

proteins

Sf9 insect cells

5 μg;10 μg;50 μg;100 μg

60;95;265;425 USD

The DLST protein is part of the 2-oxoglutarate dehydrogenase complex, which converts 2-oxoglutarate into succinyl-CoA and CO(2). It is active in the mitochondrion and plays a role in histone succinylation in the nucleus by supplying succinyl-CoA to the histone succinyltransferase KAT2A. DLST Protein, Human (sf9, His) is the recombinant human-derived DLST protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of DLST Protein, Human (sf9, His) is 386 a.a., with molecular weight of ~43.9 kDa.

Human

DLST protein functions as the dihydrolipoamide succinyltransferase (E2) component within the 2-oxoglutarate dehydrogenase complex, a key player in cellular metabolism. This complex catalyzes the conversion of 2-oxoglutarate to succinyl-CoA and CO(2), predominantly operating in the mitochondrion. Notably, a fraction of the 2-oxoglutarate dehydrogenase complex localizes in the nucleus, where DLST is crucial for lysine succinylation of histones. DLST associates with KAT2A on chromatin, providing succinyl-CoA to histone succinyltransferase KAT2A. This dual localization underscores DLST's pivotal role in coordinating metabolic processes within the mitochondria and contributing to epigenetic modifications in the nucleus, highlighting its multifaceted functionality in cellular homeostasis.

2-oxoglutarate dehydrogenase complex component E2; OGDC-E2; E2K; DLST; DLTS

Greater than 90% as determined by reducing SDS-PAGE.

Supplied as a 0.2 μm filtered solution of 20 mM Tris, 300 mM NaCl, pH 7.5, 10% Glycerol.

Shipping with dry ice