protein

G-CSFR/CD114 Protein, Human (HEK293, His)

HY-P75694

5 μg;10 μg;50 μg;100 μg

49;84;235;400 USD

G-CSFR/CD114 Protein, Human (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

49;84;235;400 USD

The G-CSFR/CD114 protein, as a receptor for granulocyte colony-stimulating factor (CSF3), is essential for granulocyte maturation and plays a key role in the proliferation, differentiation, and survival of neutrophil lineage cells. Furthermore, it may be involved in cell surface adhesion or recognition events. G-CSFR/CD114 Protein, Human (HEK293, His) is the recombinant human-derived G-CSFR/CD114 protein, expressed by HEK293 , with C-His labeled tag. The total length of G-CSFR/CD114 Protein, Human (HEK293, His) is 603 a.a., with molecular weight of 90-110 kDa.

Human

G-CSFR/CD114, the receptor for granulocyte colony-stimulating factor (CSF3), holds a pivotal role in orchestrating granulocytic maturation by governing the proliferation, differentiation, and survival of cells along the neutrophilic lineage. This homodimeric receptor engages with two CSF3 molecules, forming a crucial interaction that regulates essential cellular processes. Beyond its involvement in cellular maturation, G-CSFR/CD114 may contribute to adhesion or recognition events at the cell surface. Furthermore, its interaction with CEACAM1 serves as a regulatory axis, down-regulating the CSF3R-STAT3 pathway by recruiting PTPN6, which subsequently dephosphorylates CSF3R and modulates cellular signaling dynamics.

Granulocyte colony-stimulating factor receptor; G-CSF-R; CD114; CSF3R; GCSFR

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

Room temperature in continental US; may vary elsewhere.