protein

CMBL Protein, Human (His)

HY-P75679

5 μg;10 μg;100 μg

45;75;340 USD

CMBL Protein, Human (His)

proteins

E. coli

5 μg;10 μg;100 μg

45;75;340 USD

The CMBL protein is a cysteine hydrolase that converts olmesartan medoxomil to its active form olmesartan, an angiotensin receptor blocker. It may also activate beta-lactam antibiotics such as faropenem etexil and renamcillin. CMBL Protein, Human (His) is the recombinant human-derived CMBL protein, expressed by E. coli , with N-His labeled tag. The total length of CMBL Protein, Human (His) is 245 a.a., with molecular weight of ~28 kDa.

Human

The CMBL protein functions as a cysteine hydrolase, demonstrating the capability to convert the prodrug olmesartan medoxomil into its active metabolite olmerstatan, an angiotensin receptor blocker, primarily within the liver and intestine. Additionally, CMBL may play a role in the activation of beta-lactam antibiotics, such as faropenem medoxomil and lenampicillin. Its enzymatic activity is strongly inhibited by p-chloromercuribenzoate (PCMB) and partially inhibited by bis-p-nitrophenylphosphate (BNPP). Notably, CMBL remains unaffected by inhibitors such as DFP, PMSF, eserine, or EDTA.

Carboxymethylenebutenolidase homolog; CMBL

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris, 0.1% Brij35, pH 8.0 or 50 mM Tris-HCL, 300 mM NaCl, pH 8.0.

Room temperature in continental US; may vary elsewhere.