protein

CD146/MCAM Protein, Human (HEK293, Fc)

HY-P75611

10 μg;50 μg;100 μg

80;200;320 USD

CD146/MCAM Protein, Human (HEK293, Fc)

proteins

HEK293

10 μg;50 μg;100 μg

80;200;320 USD

The CD146/MCAM protein is critical for maintaining endothelial monolayer integrity and cell adhesion in vascular tissue. Its expression promotes the interaction of melanoma cells with the vasculature and may contribute to tumor spread through the bloodstream. CD146/MCAM Protein, Human (HEK293, Fc) is the recombinant human-derived CD146/MCAM protein, expressed by HEK293 , with C-hFc labeled tag.

Human

The CD146/MCAM protein plays a crucial role in cell adhesion and maintaining the integrity of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression enables melanoma cells to interact with the cellular components of the vascular system, potentially promoting the spread of tumors through the bloodstream. During embryonic development, CD146/MCAM may function as an adhesion molecule in neural crest cells. It acts as a surface receptor, initiating the tyrosine phosphorylation of FYN and PTK2/FAK1, and leading to a transient rise in intracellular calcium levels.

Cell surface glycoprotein MUC18; CD146; MCAM; MUC18

Greater than 95% as determined by reducing SDS-PAGE

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

Shipping with dry ice