protein

Neprilysin/CD10 Protein, Rhesus Macaque (HEK293, His)

HY-P75607

5 μg;10 μg;50 μg;100 μg

60;100;280;480 USD

Neprilysin/CD10 Protein, Rhesus Macaque (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

60;100;280;480 USD

MME is a cell-surface peptidase member of the M13 family of zinc peptidases, which also includes endothelin converting enzymes (ECE-1 and ECE-2), KELL and PEX. MME cleaves peptide bonds on the amino side of hydrophobic amino acids and is the key enzyme in processing of a variety of physiologically active peptides, such as GRP, neurotensin (NT), and vasoactive intestinal peptide (VIP). MME is downregulated in nearly 50% of primary and metastatic prostate cancers. Neprilysin/CD10 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived Neprilysin/CD10 protein, expressed by HEK293 , with N-His labeled tag. The total length of Neprilysin/CD10 Protein, Rhesus Macaque (HEK293, His) is 699 a.a., with molecular weight of ~82.1 kDa.

Rhesus Macaque

MME is a cell-surface peptidase member of the M13 family of zinc peptidases, which also includes endothelin converting enzymes (ECE-1 and ECE-2), KELL and PEX. MME cleaves peptide bonds on the amino side of hydrophobic amino acids and is the key enzyme in processing of a variety of physiologically active peptides, such as GRP, neurotensin (NT), and vasoactive intestinal peptide (VIP). MME is downregulated in nearly 50% of primary and metastatic prostate cancers, independently predicting an inferior prognosis. In addition to its downregulation by androgen withdrawal, MME expression is also downregulated by methylation, suggesting its tumor-suppressive effects. Indeed, MME expression reduces growth, motility, and survival of prostate cancer cells in cell culture. Consistent with these observations, replacements of MME inhibit tumorigenicity of prostate cancer cells in xenograft experiments [1] .

Neprilysin; Atriopeptidase; CALLA; NEP; SFE; CD10; MME

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.