protein

CBR3 Protein, Human (His)

HY-P75605

5 μg;10 μg;50 μg;100 μg

75;125;355;600 USD

CBR3 Protein, Human (His)

proteins

E. coli

5 μg;10 μg;50 μg;100 μg

75;125;355;600 USD

The CBR3 protein uses NADPH to convert carbonyl compounds into alcohols. CBR3 Protein, Human (His) is the recombinant human-derived CBR3 protein, expressed by E. coli , with N-His labeled tag. The total length of CBR3 Protein, Human (His) is 277 a.a., with molecular weight of ~37 kDa.

Human

CBR3, a multifaceted enzyme, catalyzes the NADPH-dependent reduction of various carbonyl compounds, transforming them into their respective alcohols. Although it exhibits low NADPH-dependent oxidoreductase activity, CBR3 is particularly effective on orthoquinones, including 1,2-naphthoquinone, showcasing its potential role in protecting against the cytotoxic effects of exogenous quinones. The enzyme is not limited to quinones, as it also acts on non-quinone compounds like isatin and the anticancer drug oracin. CBR3's preference for ortho-quinones over paraquinones highlights its substrate specificity. Notably, no endogenous substrate, aside from isatin, has been identified for CBR3, underscoring its versatility and potential contributions to cellular detoxification processes.

Carbonyl reductase [NADPH] 3; NADPH-dependent carbonyl reductase 3; CBR3

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of 50 mM Tris, 300 mM NaCl, 5% trehalose, 5% mannitol and 0.01% Tween80, pH 7.4.

Room temperature in continental US; may vary elsewhere.