protein

BACE2 Protein, Mouse (HEK293, His)

HY-P75588

5 μg;10 μg;50 μg

40;70;200 USD

BACE2 Protein, Mouse (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg

40;70;200 USD

The BACE2 protein is critically involved in the proteolytic processing of amyloid precursor protein (APP), producing beta-cleaved soluble APP and a cell-associated C-terminal fragment. It cleaves APP at residues 690-691 and 671-672. BACE2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived BACE2 protein, expressed by HEK293 , with C-His labeled tag. The total length of BACE2 Protein, Mouse (HEK293, His) is 443 a.a., with molecular weight of ~55 kDa.

Mouse

The BACE2 protein assumes a critical role in the proteolytic processing of the amyloid precursor protein (APP), cleaving it between residues 690 and 691. This cleavage event results in the generation and extracellular release of beta-cleaved soluble APP and a corresponding cell-associated C-terminal fragment, later released by gamma-secretase. Additionally, BACE2 has been shown to cleave APP between residues 671 and 672. Beyond its involvement with APP, BACE2 plays a pivotal role in the proteolytic shedding of PMEL during early stages of melanosome biogenesis, cleaving PMEL within the M-beta fragment to release the amyloidogenic PMEL luminal fragment comprising M-alpha and a small portion of M-beta N-terminus. This cleavage step is crucial for the subsequent processing and assembly of PMEL fibrils into amyloid sheets. Furthermore, BACE2 is responsible for the proteolytic processing of CLTRN in pancreatic beta cells, highlighting its diverse functions in cellular processes and contributing to our understanding of its significance in various physiological contexts.

Beta-secretase 2; Aspartyl protease 1; ASP1; Memapsin-1; Bace2

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.