protein

Allergin-1 Protein, Human (HEK293, His)

HY-P75575

5 μg;10 μg;50 μg;100 μg

45;75;210;340 USD

Allergin-1 Protein, Human (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

45;75;210;340 USD

Allergin-1 Protein, an immunoglobulin-like receptor, crucially acts as a negative regulator in mast cells, inhibiting degranulation. Operating as a monomer, it interacts with signaling molecules like tyrosine-phosphorylated PTPN6, PTPN11, and INPP5D, forming complexes that suppress IgE-mediated mast cell activation, thus dampening type I immediate hypersensitivity reactions. Allergin-1 Protein, Human (HEK293, His) is the recombinant human-derived Allergin-1 protein, expressed by HEK293 , with C-His labeled tag.

Human

Allergin-1 Protein, an immunoglobulin-like receptor, functions as a negative regulator in mast cells by inhibiting degranulation. Specifically, it plays a crucial role in suppressing IgE-mediated mast cell activation, thereby dampening the type I immediate hypersensitivity reaction. Allergin-1 operates as a monomer and interacts with key signaling molecules, including tyrosine-phosphorylated PTPN6, PTPN11, and INPP5D, forming complexes that contribute to its inhibitory effects on mast cell degranulation.

Allergy inhibitory receptor 1; MCA-32; MILR1; C17orf60; MCA32

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.