protein

ADAM15 Protein, Mouse (HEK293, His)

HY-P75564

2 μg;5 μg;10 μg;50 μg;100 μg

30;53;85;220;350 USD

ADAM15 Protein, Mouse (HEK293, His)

proteins

HEK293

2 μg;5 μg;10 μg;50 μg;100 μg

30;53;85;220;350 USD

ADAM15 is an active metalloprotease that plays a crucial role in physiological processes and has gelatin-solubilizing and collagen-solubilizing activities. Notably, it affects wound healing, mediates intraepithelial cell/T cell interactions, and inhibits β-1 integrin-mediated cell adhesion and migration in airway smooth muscle cells. ADAM15 Protein, Mouse (HEK293, His) is the recombinant mouse-derived ADAM15 protein, expressed by HEK293 , with C-His labeled tag. The total length of ADAM15 Protein, Mouse (HEK293, His) is 680 a.a., with molecular weight of 75-110 kDa.

Mouse

ADAM15, an active metalloproteinase, exhibits gelatinolytic and collagenolytic activity, playing a crucial role in diverse physiological processes. Its involvement in wound healing is notable, and it mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Additionally, ADAM15 functions in inhibiting beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells, suppressing cell motility on or towards fibronectin by potentially influencing alpha-v/beta-1 integrin cell surface expression through ERK1/2 inactivation. Notably, ADAM15 cleaves E-cadherin in response to growth factor deprivation and contributes to glomerular cell migration, suggesting its involvement in various cellular events. Furthermore, its role in pathological neovascularization and potential contribution to cartilage remodeling underscore its multifaceted functions. ADAM15 may undergo proteolytic processing during sperm epididymal maturation and the acrosome reaction, potentially playing a role in sperm-egg binding through interactions with egg membrane receptors, particularly integrins.

Disintegrin and metalloproteinase domain-containing protein 15; ADAM 15; MDC-15; Metargidin

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.