protein

14-3-3 beta Protein, Cynomolgus

HY-P75550

5 μg;10 μg;50 μg;100 μg;500 μg;1 mg

45;78;220;350;980;1665 USD

14-3-3 beta Protein, Cynomolgus

proteins

E. coli

5 μg;10 μg;50 μg;100 μg;500 μg;1 mg

45;78;220;350;980;1665 USD

14-3-3 beta proteins act as adapters, binding to phosphoserine or phosphothreonine motifs in different signaling pathways, regulating chaperone activity. It negatively regulates osteogenesis by blocking the nuclear translocation of phosphorylated SRPK2 and counteracting the pro-apoptotic effect of SRPK2 through cyclin D1 expression. 14-3-3 beta Protein, Cynomolgus is the recombinant cynomolgus-derived 14-3-3 beta protein, expressed by E. coli , with tag free. The total length of 14-3-3 beta Protein, Cynomolgus is 244 a.a., with molecular weight of ~28 kDa.

Cynomolgus

14-3-3 beta protein serves as an adapter involved in the regulation of diverse signaling pathways, engaging with numerous partners through recognition of phosphoserine or phosphothreonine motifs. The resulting interactions typically modulate the activity of the binding partner. Functioning as a negative regulator of osteogenesis, it impedes the nuclear translocation of the phosphorylated form of SRPK2, counteracting SRPK2's stimulatory effect on cyclin D1 expression and thereby preventing neuronal apoptosis. Additionally, 14-3-3 beta negatively regulates signaling cascades that activate MAP kinases via AKAP13. Existing as a homodimer, it interacts with various proteins, including SAMSN1, PRKCE, AKAP13, SSH1, TORC2/CRTC2, ABL1, ROR2, GAB2, YAP1, SRPK2, AANAT, MYO1C, SIRT2, DAPK2, PI4KB, TBC1D22A, TBC1D22B, SOS1, SLITRK1, SYNPO2, RIPOR2, MARK2, MARK3, TESK1, MEFV, HDAC4, and ADAM22, participating in diverse cellular processes.

KCIP-1; 14-3-3 protein beta/alpha; GW128; Protein 1054; YWHAB

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, 10% Glycerol, 0.5 mM DTT, pH 7.5. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

Room temperature in continental US; may vary elsewhere.