protein

AGRP Protein, Human (HEK293, His)

HY-P75526

50 μg;100 μg

250;400 USD

AGRP Protein, Human (HEK293, His)

proteins

HEK293

50 μg;100 μg

250;400 USD

AGRP proteins critically regulate body weight homeostasis and feeding behavior through the central melanocortin system. As an α-melanocyte-stimulating hormone antagonist, AGRP inhibits cAMP production and antagonizes stimulation of melanocortin receptors. AGRP Protein, Human (HEK293, His) is the recombinant human-derived AGRP protein, expressed by HEK293 , with C-His labeled tag.

Human

The AGRP protein plays a crucial role in weight homeostasis and is integral to the regulation of feeding behavior through the central melanocortin system. Functioning as an alpha melanocyte-stimulating hormone antagonist, AGRP inhibits cAMP production mediated by the stimulation of melanocortin receptors within the hypothalamus and adrenal gland. While exhibiting minimal activity with MC5R, AGRP serves as an inverse agonist for MC3R and MC4R, suppressing their constitutive activity. Moreover, AGRP promotes the endocytosis of MC3R and MC4R in an arrestin-dependent manner, underscoring its intricate involvement in modulating the activity of melanocortin receptors. The interaction of AGRP with MC3R, MC4R, and MC5R further highlights its regulatory role in the melanocortin signaling pathway, positioning it as a key player in the intricate balance of weight regulation and feeding control.

Agouti-related protein; AGRP; AGRT; ART

Greater than 90% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.2 or PBS, pH 7.2, 5% trehalose, 5% mannitol and 0.01% Tween80.

Room temperature in continental US; may vary elsewhere.