protein

AKT3 Protein, Human (sf9, GST)

HY-P75519

10 μg;50 μg

210;600 USD

AKT3 Protein, Human (sf9, GST)

proteins

Sf9 insect cells

10 μg;50 μg

210;600 USD

The AKT3 protein, like AKT1 and AKT2, is an important member of the AKT kinase family and plays a central role in a variety of cellular processes, including metabolism, proliferation, survival, growth, and angiogenesis. AKT3 has more than 100 reported targets and coordinates complex signaling pathways that control glucose uptake, regulate glycogen storage, and influence neurogenesis. AKT3 Protein, Human (sf9, GST) is the recombinant human-derived AKT3 protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of AKT3 Protein, Human (sf9, GST) is 479 a.a., with molecular weight of ~81 kDa.

Human

AKT2, a crucial member of the AKT kinase family along with AKT1 and AKT3, orchestrates a myriad of cellular processes, including metabolism, proliferation, cell survival, growth, and angiogenesis. Operating through the phosphorylation of numerous downstream substrates, AKT2 influences over 100 reported targets, exhibiting remarkable functional diversity. It governs insulin-induced glucose uptake by facilitating SLC2A4/GLUT4 translocation and intricately regulates insulin signaling pathways. Additionally, AKT2 modulates glycogen storage, inhibits GSK3 kinase activity, and plays a pivotal role in the AKT-mTOR signaling pathway, influencing neurogenesis and cellular migration dynamics. AKT2's involvement in phosphorylating FOXO factors, CREB1, and multiple targets related to metabolism underscores its pivotal position in cellular homeostasis. Notably, AKT2 exhibits isoform-specific functions, with a significant role in regulating glucose uptake and participating in intricate processes such as skeletal muscle differentiation. The recent identification of specific substrates like PITX2 and ANKRD2 further delineates AKT2's nuanced and intricate cellular regulatory roles.

RAC-gamma serine/threonine-protein kinase; Protein kinase Akt-3; PKB gamma; Akt3

Greater than 90% as determined by reducing SDS-PAGE

Supplied as sterile 50 mM Tris, 100 mM NaCl, 20% Glycerol, pH 8.0.

Shipping with dry ice