protein

Angiopoietin-2 Protein, Dog (HEK293, His)

HY-P75509

2 μg;10 μg;50 μg;100 μg;500 μg

35;60;150;260;750 USD

Angiopoietin-2 Protein, Dog (HEK293, His)

proteins

HEK293

2 μg;10 μg;50 μg;100 μg;500 μg

35;60;150;260;750 USD

ANGPT2/Angiopoietin-2 (dog) complexly regulates angiogenesis by binding to TEK/TIE2, competitively affecting ANGPT1 signaling. It independently induces TEK/TIE2 phosphorylation and, in the absence of VEGF, may cause endothelial cell apoptosis, thereby promoting vascular regression. Angiopoietin-2 Protein, Dog (HEK293, His) is the recombinant dog-derived Angiopoietin-2 protein, expressed by HEK293 , with N-His labeled tag.

Dog

The Dog Angiopoietin-2 protein (ANGPT2) engages in a multifaceted role as it binds to TEK/TIE2, competing for the ANGPT1 binding site and effectively modulating ANGPT1 signaling. Notably, ANGPT2 has the capacity to induce tyrosine phosphorylation of TEK/TIE2 even in the absence of ANGPT1. Its function extends to angiogenesis regulation, where in the absence of angiogenic inducers like VEGF, ANGPT2-mediated loosening of cell-matrix contacts may lead to endothelial cell apoptosis, contributing to vascular regression. Conversely, in collaboration with VEGF, ANGPT2 can facilitate endothelial cell migration and proliferation, acting as a permissive angiogenic signal. Furthermore, ANGPT2 is implicated in the regulation of lymphangiogenesis. The protein's interactions with TEK/TIE2, competing for the same binding site as ANGPT1, and with ITGA5 underscore its comprehensive role in angiogenesis and vascular regulation within the context of dog biology.

Angiopoietin-2; ANG-2; ANGPT2

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.