protein

B7-H2/ICOSLG Protein, Rat (HEK293, His)

HY-P75486

5 μg;10 μg;50 μg;100 μg;500 μg

45;70;180;305;860 USD

B7-H2/ICOSLG Protein, Rat (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg;500 μg

45;70;180;305;860 USD

B7-H2/ICOSLG Protein, a ligand for T-cell receptor ICOS, critically costimulates T-cell proliferation and cytokine secretion. It induces B-cell proliferation and supports plasma cell differentiation, playing a key role in local tissue responses to inflammation. B7-H2/ICOSLG also modulates the secondary immune response by co-stimulating memory T-cell function. In molecular interactions, it has been observed to interact with CTLA4 in vitro. B7-H2/ICOSLG Protein, Rat (HEK293, His) is the recombinant rat-derived B7-H2/ICOSLG protein, expressed by HEK293 , with C-His labeled tag.

Rat

B7-H2/ICOSLG protein serves as a ligand for the T-cell-specific cell surface receptor ICOS, functioning as a critical costimulatory signal for T-cell proliferation and cytokine secretion. Additionally, it induces B-cell proliferation and facilitates their differentiation into plasma cells. This protein is poised to play a significant role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function. In molecular interactions, B7-H2/ICOSLG has been shown to interact with CTLA4 in vitro.

ICOS ligand; B7-H2; ICOSLG; LICOS; B7RP-1; CD275

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.