protein

BMP-5 Protein, Human (HEK293, hFc)

HY-P75472

5 μg;10 μg;50 μg

53;90;250 USD

BMP-5 Protein, Human (HEK293, hFc)

proteins

HEK293

5 μg;10 μg;50 μg

53;90;250 USD

Bone morphogenetic protein 5 (BMP-5) is a pleiotropic ligand protein belonging to the TGFβ family, which is mainly expressed in the lung and liver. After BMP-5 silencing, the activity of p38/ERK signaling pathway can be down-regulated to inhibit chondrocyte senescence and apoptosis and knee arthritis (OA) [1] . Bmp-5 initiates typical BMP signaling cascades by binding to type I receptor BMPR1A and type II receptor BMPR2 [2] , or triggers signals through atypical pathways such as MAPK p38 signaling cascades to promote chondrogenic differentiation [3] . The total length of human BMP-5 protein is 454 amino acids (M1-H454), with 4 glycosylation domains. BMP-5 Protein, Human (HEK293, hFc) has a total length of 131 amino acids (Q324-H454), is expressed in HEK293 cells with a N-terminal hFc-tag.

Human

Bone Morphogenetic Protein 5 (BMP-5) is a ligand protein with pleiotropic, belongs to TGFβ family and expresses mainly in the lung and liver. BMP/TGFβ signaling to involve in vascular and valvular homeostasis, which is a critical process of embryonic development [4] . And BMP/TGFβ signaling can be terminated by inhibitory SMADs including SMAD6 and SMAD7, which are activated and induced by BMP signaling and switch off BMP signaling via multiple mechanisms [5] . BMP-5 silencing inhibits chondrocyte senescence and apoptosis as well as osteoarthritis (OA) progression by downregulating activity in the p38/ERK signaling pathway [1] . BMP-5 initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2 [2] . BMP-5 also triggers signal through non-canonical pathway such as MAPK p38 signaling cascade to promote chondrogenic differentiation [3] . BMP-5 specific expressing in neural crest progenitor cells is sufficient to induce cell proliferation through the MEK-ERK-ID3 signaling cascade, whereas disruption of this signaling cascade had no effect on cell survival [6] .

Bone morphogenetic protein 5; BMP-5

Greater than 90% as determined by reducing SDS-PAGE.

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

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