protein

C1QB Protein, Human (sf9, His)

HY-P75464

5 μg;10 μg;50 μg

50;75;215 USD

C1QB Protein, Human (sf9, His)

proteins

Sf9 insect cells

5 μg;10 μg;50 μg

50;75;215 USD

The C1QB protein plays a critical role in the assembly of C1, the initial component of the serum complement system. C1q binds to the zymogens C1r and C1s, resulting in C1 assembly. C1QB Protein, Human (sf9, His) is the recombinant human-derived C1QB protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of C1QB Protein, Human (sf9, His) is 226 a.a., with molecular weight of ~30 kDa.

Human

C1QB protein plays a crucial role in the formation of C1, the initial component of the serum complement system. C1q associates with the proenzymes C1r and C1s, resulting in the assembly of C1. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 occurs upon engagement of the globular heads of C1q with the Fc regions of IgG or IgM antibodies within immune complexes. C1, in its active form, constitutes a calcium-dependent trimolecular complex composed of C1q, C1r, and C1s in a molar ratio of 1:2:2. The C1q subcomponent consists of nine subunits, with six being disulfide-linked dimers of the A and B chains, and the remaining three forming disulfide-linked dimers of the C chain.

Complement C1q subcomponent subunit B; C1QB

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 50 mM Tris, 100 mM NaCl, 10% Glycerol, 0.5 mM TCEP, pH 7.5. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

Shipping with dry ice