protein

CADM1/IGSF4A Protein, Human (HEK293, His)

HY-P75462

5 μg;10 μg;50 μg;100 μg;500 μg

40;67;188;320;900 USD

CADM1/IGSF4A Protein, Human (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg;500 μg

40;67;188;320;900 USD

The CADM1/IGSF4A protein is an important mediator of cell-cell adhesion.It forms homodimers and interacts with CADM3 and NECTIN3.CADM1/IGSF4A Protein, Human (HEK293, His) is the recombinant human-derived CADM1/IGSF4A protein, expressed by HEK293 , with C-His labeled tag.

Human

The CADM1/IGSF4A protein serves as a pivotal mediator of both homophilic and heterophilic cell-cell adhesion, operating in a Ca(2+)-independent manner. It forms homodimers and mediates homophilic adhesion, and also engages in heterophilic interactions with CADM3 and NECTIN3. The interaction between CADM1 and CRTAM promotes natural killer (NK) cell cytotoxicity, interferon-gamma (IFN-gamma) secretion by CD8+ cells, and NK cell-mediated rejection of tumors expressing CADM1. In mast cells, CADM1 plays a crucial role in attachment to and communication with nerves, being essential for mast cell development and survival in vivo. Furthermore, CADM1 is involved in the regulation of T-cell retention within the draining lymph node, required for the intestinal retention of specific T-cell subsets, and contributes to the adhesion of T-cells to gut-associated dendritic cells. Additionally, CADM1 functions as a synaptic cell adhesion molecule, playing roles in dendritic spine formation and synapse assembly. It is implicated in neuronal processes such as migration, axon growth, pathfinding, and fasciculation. Moreover, CADM1 is involved in spermatogenesis, contributing to the adhesion of spermatocytes and spermatids to Sertoli cells. In non-small-cell lung cancer (NSCLC) cells, CADM1 acts as a tumor suppressor, influencing invasive phenotypes. It forms homodimers via its Ig-like V-type domain and interacts with various proteins, including FARP1, CRTAM, EPB41L3/DAL1, MPP2, MPP3, and PALS2, facilitating diverse cellular functions and signaling pathways.

Cell adhesion molecule 1; IgSF4; NECL-2; SynCAM; TSLC-1

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Room temperature in continental US; may vary elsewhere.