protein

CALM2 Protein, Human (His)

HY-P75461

5 μg;10 μg;50 μg;100 μg

30;45;120;190 USD

CALM2 Protein, Human (His)

proteins

E. coli

5 μg;10 μg;50 μg;100 μg

30;45;120;190 USD

The CALM2 protein is an important component of calcium signaling, controlling enzymes, ion channels, and aquaporins through calcium binding. CALM2 Protein, Human (His) is the recombinant human-derived CALM2 protein, expressed by E. coli , with N-His labeled tag. The total length of CALM2 Protein, Human (His) is 149 a.a., with molecular weight of ~19 kDa.

Human

CALM2 (Calmodulin 2) serves as a critical component in calcium signal transduction pathways, playing a pivotal role in the regulation of numerous enzymes, ion channels, aquaporins, and other proteins through its calcium-binding capabilities. The activation of calmodulin is contingent upon calcium binding, enabling it to exert control over various cellular processes. Notably, the calmodulin-calcium complex stimulates a range of enzymes, including myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), as well as phosphatases. CALM2, in conjunction with CCP110 and centrin, participates in a genetic pathway that governs the centrosome cycle and progression through cytokinesis. Additionally, CALM2 mediates calcium-dependent inactivation of CACNA1C and positively regulates the calcium-activated potassium channel activity of KCNN2. Furthermore, in the context of microbial infection, CALM2 is required for the arginine ADP-ribosanase activity of C.violaceum CopC. These multifaceted functions underscore CALM2's integral role in orchestrating cellular responses to calcium signals.

Calmodulin-2; CAM2; CAMB

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.