protein

CD14 Protein, Cynomolgus (HEK293, His)

HY-P75445

5 μg;10 μg;50 μg;100 μg;500 μg;1 mg

40;65;180;290;810;1300 USD

CD14 Protein, Cynomolgus (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg;500 μg;1 mg

40;65;180;290;810;1300 USD

CD14 protein is a key coreceptor that cooperates with LBP to bind LPS and deliver it to the LY96/TLR4 complex to generate an immune response. CD14 activates NF-kappa-B through MyD88, TIRAP and TRAF6, triggering inflammation and cytokine release. CD14 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived CD14 protein, expressed by HEK293 , with C-His labeled tag. The total length of CD14 Protein, Cynomolgus (HEK293, His) is 344 a.a., with molecular weight of 45-56 kDa.

Cynomolgus

CD14 Protein serves as a key coreceptor for bacterial lipopolysaccharide (LPS), collaborating with LBP to bind monomeric LPS and deliver it to the LY96/TLR4 complex, thereby orchestrating the innate immune response. Operating through MyD88, TIRAP, and TRAF6, CD14 activates NF-kappa-B, triggering cytokine release and inflammation. It also functions as a coreceptor for TLR2:TLR6 and TLR2:TLR1 heterodimers in response to diacylated and triacylated lipopeptides, respectively. Additionally, CD14 binds electronegative LDL, mediating cytokine release induced by LDL(-). As a member of the lipopolysaccharide (LPS) receptor complex, which includes CD14, LY96, and TLR4, CD14 interacts with LPAR1, highlighting its versatile roles in immune and signaling pathways.

Monocyte Differentiation Antigen CD14; CD14

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.