protein

CD98 Protein, Human (HEK293, His)

HY-P75368

5 μg;10 μg;50 μg;100 μg;500 μg;1 mg

50;86;240;408;1100;1700 USD

CD98 Protein, Human (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg;500 μg;1 mg

50;86;240;408;1100;1700 USD

The CD98 protein acts as a chaperone, promoting the biogenesis and trafficking of functional transporter heterodimers to the plasma membrane. It forms heterodimers with various SLC7 family transporters and affects the substrate specificity of amino acid antiporters. CD98 Protein, Human (HEK293, His) is the recombinant human-derived CD98 protein, expressed by HEK293 , with N-His labeled tag. The total length of CD98 Protein, Human (HEK293, His) is 425 a.a., with molecular weight of 60-80 kDa.

Human

CD98 protein functions as a chaperone that aids in the biogenesis and trafficking of functional transporter heterodimers to the plasma membrane. It forms heterodimers with various SLC7 family transporters, including SLC7A5, SLC7A6, SLC7A7, SLC7A8, SLC7A10, and SLC7A11, acting as amino acid antiporters with substrate specificity determined by the SLC7A subunit. For instance, the heterodimer SLC3A2/SLC7A11 functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate. Additionally, SLC3A2/SLC7A5, when associated with LAPTM4B, is recruited to lysosomes, promoting leucine uptake and mTORC1 activation. CD98 is essential for plasma membrane localization, stability, and transport activity of various SLC7 transporters. Moreover, it plays a pivotal role in modulating integrin-related signaling, contributing to cell spreading, migration, and tumor progression. In the context of hepatitis C virus (HCV) infection, the SLC3A2 and SLC7A5/LAT1 complex facilitates viral entry into host cells and increases L-leucine uptake, thereby enhancing mTORC1 signaling activation and contributing to HCV-mediated pathogenesis.

4F2 cell-surface antigen heavy chain; 4F2hc; CD98; SLC3A2

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

Room temperature in continental US; may vary elsewhere.