protein

CLEC1B/CLEC-2 Protein, Mouse (HEK293, Fc)

HY-P75335

2 μg;5 μg;10 μg;50 μg;100 μg

30;50;80;215;340 USD

CLEC1B/CLEC-2 Protein, Mouse (HEK293, Fc)

proteins

HEK293

2 μg;5 μg;10 μg;50 μg;100 μg

30;50;80;215;340 USD

The CLEC1B/CLEC-2 protein serves as a platelet receptor for PDPN. When activated, it signals through SRC and SYK kinases, activating PLCG2. CLEC1B forms homodimers and interacts with RACK1, promoting its ubiquitination and degradation. It also interacts with SYK and PDPN, independently of glycosylation, activating CLEC1B/CLEC-2. CLEC1B/CLEC-2 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived CLEC1B/CLEC-2 protein, expressed by HEK293 , with N-hFc labeled tag. The total length of CLEC1B/CLEC-2 Protein, Mouse (HEK293, Fc) is 177 a.a., with molecular weight of 50-65 kDa.

Mouse

CLEC1B/CLEC-2 Protein is a C-type lectin-like receptor that serves as a platelet receptor for PDPN, a marker of lymphatic endothelial cells. Upon ligand activation, CLEC1B/CLEC-2 signals through the sequential activation of SRC and SYK tyrosine kinases, ultimately leading to the activation of PLCG2. It forms homodimers and interacts with RACK1 through its cytoplasmic domain, promoting CLEC1B ubiquitination and subsequent degradation via the proteasome pathway. Additionally, CLEC1B/CLEC-2 interacts with SYK in a dimeric form, facilitated by the SH2 domains of SYK. Furthermore, it interacts with PDPN, and this interaction is independent of CLEC1B glycosylation, resulting in the activation of CLEC1B/CLEC-2.

C-type lectin domain family 1 member B; CLEC1B; CLEC2

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.