protein

Complement C3 Protein, Cynomolgus (HEK293, His)

HY-P75332

5 μg;10 μg;50 μg;100 μg

42;72;200;340 USD

Complement C3 Protein, Cynomolgus (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

42;72;200;340 USD

Complement C3 proteins play a key role in initiating the complement system through processing by C3 convertase in the classical and alternative pathways. Upon activation, C3b covalently binds to the surface, while C3a (anaphylatoxin produced by proteolysis of C3) mediates local inflammation. Complement C3 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived Complement C3 protein, expressed by HEK293 , with C-His labeled tag. The total length of Complement C3 Protein, Cynomolgus (HEK293, His) is 1641 a.a., with molecular weight of ~186.40 kDa.

Cynomolgus

C3 assumes a pivotal role in the initiation of the complement system, and its processing by C3 convertase constitutes a central reaction in both classical and alternative complement pathways. Following activation, C3b has the capacity to covalently bind to cell surface carbohydrates or immune aggregates through its reactive thioester. Concurrently, the anaphylatoxin C3a, derived from the proteolytic degradation of complement C3, serves as a mediator in local inflammatory processes. In instances of chronic inflammation, C3a acts as a chemoattractant for neutrophils, inducing smooth muscle contraction, increasing vascular permeability, and triggering histamine release from mast cells and basophilic leukocytes.

Anaphylatoxin; C3; Complement Component C3a

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.