protein

CRIPT Protein, Human (His)

HY-P75331

5 μg;10 μg;50 μg;100 μg

100;170;480;815 USD

CRIPT Protein, Human (His)

proteins

E. coli

5 μg;10 μg;50 μg;100 μg

100;170;480;815 USD

CRIPT is a key member of the small spliceosome and plays a crucial role in U12-type intron splicing, contributing to the complexity of RNA splicing. CRIPT Protein, Human (His) is the recombinant human-derived CRIPT protein, expressed by E. coli , with N-His labeled tag. The total length of CRIPT Protein, Human (His) is 101 a.a., with molecular weight of ~14 kDa.

Human

CRIPT, a crucial participant in the minor spliceosome, plays a significant role in the splicing of U12-type introns in pre-mRNAs, contributing to the intricate process of RNA splicing. Beyond its role in splicing, CRIPT is involved in the cytoskeletal anchoring of DLG4 within excitatory synapses. As a component of the minor spliceosome complex, CRIPT engages in interactions with key partners such as RNF113A, SF3B1/SF3b155, SF3B2/SF3b145, and PHF5A/SF3b14b. It also exhibits a strong interaction with the PDZ3 domain of DLG4 family members, emphasizing its role in synaptic function. Additionally, CRIPT associates with microtubules, indicating its involvement in cytoskeletal dynamics. The intricate interplay of CRIPT with various molecular partners underscores its multifaceted contributions to splicing and synaptic organization.

Cysteine-rich PDZ-binding protein; CRIPT; HSPC139

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of 50 mM Tris, 300 mM NaCl, 5% trehalose, 5% mannitol and 0.01% Tween80, pH 7.4.

Room temperature in continental US; may vary elsewhere.