protein

CTLA-4 Protein, Canine (HEK293, His)

HY-P75320

5 μg;10 μg;50 μg;100 μg

35;60;150;240 USD

CTLA-4 Protein, Canine (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

35;60;150;240 USD

CTLA-4 protein inhibits T-cell responses as a critical negative regulator, with a stronger affinity for CD80 and CD86 than CD28. This affinity allows CTLA-4 to effectively suppress T-cell activation and regulate immune responses, maintaining a delicate equilibrium in T-cell-mediated immunity. CTLA-4 Protein, Canine (HEK293, His) is the recombinant canine-derived CTLA-4 protein, expressed by HEK293 , with C-His labeled tag.

Canine

CTLA-4 protein functions as a critical inhibitory receptor, playing a pivotal role as a major negative regulator in T-cell responses. The distinguishing feature of CTLA-4 lies in its significantly stronger affinity for its natural B7 family ligands, CD80 and CD86, compared to the affinity of their corresponding stimulatory coreceptor, CD28. This heightened affinity enables CTLA-4 to effectively counterbalance and suppress T-cell activation, contributing to the intricate regulation of immune responses. The dynamic interplay between CTLA-4 and its ligands underscores its significance in fine-tuning the immune system and maintaining a delicate equilibrium between activation and inhibition in T-cell-mediated immunity.

Cytotoxic T-lymphocyte associated protein 4; CTLA4; CD152

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.