protein

DAG1 Protein, Human (HEK293, His)

HY-P75311

5 μg;10 μg;50 μg;100 μg;500 μg

35;60;170;290;810 USD

DAG1 Protein, Human (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg;500 μg

35;60;170;290;810 USD

DAG1 Proteinas, a pivotal extracellular glycoprotein, is crucial for laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization. Serving as a receptor for laminin-G domain-containing extracellular matrix proteins, DAG1 interacts with laminin-2 (LAMA2) and agrin in peripheral nerve Schwann cells and acts as a receptor for laminin LAMA5. DAG1 Protein, Human (HEK293, His) is the recombinant human-derived DAG1 protein, expressed by HEK293 , with C-His labeled tag. The total length of DAG1 Protein, Human (HEK293, His) is 720 a.a., with molecular weight (glycosylation form) of ~95-110 kDa, 55-95 kDa, 17-20 kDa.

Human

Dystroglycan (DAG1) plays a crucial role in various biological processes, participating in laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization. As an extracellular peripheral glycoprotein, DAG1 serves as a receptor for extracellular matrix proteins containing laminin-G domains. Specifically, it acts as a receptor for laminin-2 (LAMA2) and agrin in peripheral nerve Schwann cells, and also functions as a receptor for laminin LAMA5.

Dystroglycan 1; Alpha-DG; Beta-DG; DAG1

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.