protein

Apolipoprotein E/APOE3 Protein, Human (HEK293, His)

HY-P7531

5 μg;10 μg;50 μg

35;55;170 USD

Apolipoprotein E/APOE3 Protein, Human (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg

35;55;170 USD

406168024

Apolipoprotein E/ApoE3 is an apolipoprotein isoform that mediates lipid transport and plays a crucial role in lipid homeostasis in both plasma and the central nervous system by binding to LDL receptors ( LDLR ), LDL receptor-related proteins ( LRP1 , LRP2 , LRP8 ), Very Low-Density Lipoprotein Receptor ( VLDLR ), and Heparin . The Apolipoprotein E/ApoE3 Protein, Human (HEK293, His) is a recombinant protein with a His tag at the N-terminus, consisting of 299 amino acids (K19-H317), and is expressed in HEK293 cells [1] .

Human

Apolipoprotein E/APOE3 is an amphiphilic molecule that interacts with both the lipid core of lipoprotein particles and the aqueous environment of plasma [3] . Apolipoprotein E/APOE3 regulates plasma and central nervous system lipid metabolism by binding to LDL receptor ( LDLR ), LDL receptor-related proteins ( LRP1 , LRP2 , LRP8 ), and Very Low-Density Lipoprotein Receptor ( VLDLR ) as well as heparin ( Heparin ) [9] [10] [12] . Apolipoprotein E/APOE3 first promotes HDL (high-density lipoprotein) synthesis by interacting with ABCA1 and then transports HDL from peripheral tissues to the liver, thereby clearing cholesterol from it. Apolipoprotein E/APOE3 plays an important role in regulating cholesterol homeostasis [11] . Apolipoprotein E/APOE can bind to the immune cell receptor LILRB4 to modulate immune responses [13] . Apolipoprotein E/APOE3 can activate MAP3K12 and atypical MAPK signaling pathways to enhance AP-1-mediated APP transcription [14] .

rHuApolipoprotein E, His; ApoE; Apolipoprotein E; APOE3

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCl, 5% Trehalose,5% Mannitol, 0.02% Tween80, pH 8.0 or 20 mM PB, 150 mM NaCl, pH 7.4 or PBS, pH 7.4, 8% trehalose.

Room temperature in continental US; may vary elsewhere.