protein

DDR1 Protein, Mouse (HEK293, His, solution)

HY-P75302

5 μg;10 μg;50 μg

35;60;170 USD

DDR1 Protein, Mouse (HEK293, His, solution)

proteins

HEK293

5 μg;10 μg;50 μg

35;60;170 USD

The DDR1 protein is a fibrillar collagen receptor that coordinates key cellular processes including matrix remodeling, migration, differentiation, survival, and proliferation. Upon collagen binding, DDR1 activates signaling cascades involving SRC and MAP kinases, promoting matrix remodeling through MMP upregulation, promoting cell migration, wound healing, and tumor invasion. DDR1 Protein, Mouse (HEK293, His, solution) is the recombinant mouse-derived DDR1 protein, expressed by HEK293 , with C-His labeled tag.

Mouse

DDR1 protein, a tyrosine kinase functioning as a cell surface receptor for fibrillar collagen, orchestrates diverse cellular processes critical for tissue homeostasis. It regulates cell attachment to the extracellular matrix, influencing matrix remodeling, cell migration, differentiation, survival, and proliferation. Upon collagen binding, DDR1 initiates a signaling cascade involving SRC and leading to MAP kinase activation. This intricate network contributes to extracellular matrix remodeling through the up-regulation of matrix metalloproteinases MMP2, MMP7, and MMP9, facilitating cell migration and wound healing, as well as promoting tumor cell invasion. DDR1's impact extends to arterial wound healing by promoting smooth muscle cell migration. Furthermore, it phosphorylates PTPN11 and is indispensable for normal blastocyst implantation during pregnancy, mammary gland differentiation, lactation, and maintenance of normal ear morphology and hearing. The multifunctional role of DDR1 underscores its significance in governing diverse physiological processes.

Epithelial discoidin domain-containing receptor 1; HGK2; CD167a; CAK; EDDR1

Greater than 95% as determined by reducing SDS-PAGE

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

Shipping with dry ice.