protein

Delta-like protein 4/DLL4 Protein, Mouse (HEK293, His)

HY-P75292

10 μg;50 μg

135;375 USD

Delta-like protein 4/DLL4 Protein, Mouse (HEK293, His)

proteins

HEK293

10 μg;50 μg

135;375 USD

Delta-like 4/DLL4 protein is a key player in the Notch signaling pathway, acting as a ligand to activate NOTCH1 and NOTCH4. In angiogenesis, DLL4 regulates endothelial cell proliferation, migration, and angiogenic sprouting. Delta-like protein 4/DLL4 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Delta-like protein 4/DLL4 protein, expressed by HEK293 , with C-His labeled tag. The total length of Delta-like protein 4/DLL4 Protein, Mouse (HEK293, His) is 525 a.a., with molecular weight of ~68 kDa.

Mouse

The Delta-like protein 4/DLL4 Protein plays a pivotal role in the Notch signaling pathway, serving as a Notch ligand and activating both NOTCH1 and NOTCH4. In the context of angiogenesis, DLL4 assumes a regulatory role by negatively influencing endothelial cell proliferation, migration, and angiogenic sprouting. The protein is essential for retinal progenitor proliferation and is required for suppressing rod fates in late retinal progenitors while contributing to the proper generation of other retinal cell types. Furthermore, during spinal cord neurogenesis, DLL4 inhibits V2a interneuron fate. Its interactions with NOTCH4 and NOTCH1 highlight the molecular basis of its role as a ligand in the Notch signaling cascade, emphasizing its multifaceted functions in orchestrating crucial cellular processes during development.

Delta-like protein 4; Delta4; DLL4

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

Room temperature in continental US; may vary elsewhere.