protein

DKK-3 Protein, Mouse (HEK293, His)

HY-P75287

5 μg;10 μg;50 μg

40;65;180 USD

DKK-3 Protein, Mouse (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg

40;65;180 USD

DKK-3 protein antagonizes canonical Wnt signaling by inhibiting LRP5/6-Wnt interaction. It forms a ternary complex with KREMEN and promotes LRP5/6 internalization. DKK-3 Protein, Mouse (HEK293, His) is the recombinant mouse-derived DKK-3 protein, expressed by HEK293 , with C-His labeled tag.

Mouse

The DKK-3 protein is involved in antagonizing canonical Wnt signaling by inhibiting the interaction between LRP5/6 and Wnt. It achieves this through the formation of a ternary complex with the transmembrane protein KREMEN, which facilitates the internalization of LRP5/6. DKKs, including DKK-3, are crucial in vertebrate development as they locally inhibit Wnt-regulated processes such as antero-posterior axial patterning, limb development, somitogenesis, and eye formation. In adult organisms, DKKs are implicated in bone formation, bone diseases, cancer, and Alzheimer's disease. Additionally, DKK-3 interacts with LRP5 and LRP6 proteins. It is important to note that DKK-3 does not possess carboxypeptidase activity or dipeptidyl-peptidase IV type activity.

Dickkopf-related protein 3; Dickkopf-3; Dkk-3; mDkk-3

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.