protein

DR6/TNFRSF21 Protein, Rat (HEK293, Fc)

HY-P75277

2 μg;10 μg;50 μg

35;60;170 USD

DR6/TNFRSF21 Protein, Rat (HEK293, Fc)

proteins

HEK293

2 μg;10 μg;50 μg

35;60;170 USD

DR6/TNFRSF21 protein is the core of apoptosis and may activate NF-kappa-B and promote BAX-mediated apoptosis through cytochrome c release. In neuronal apoptosis, it responds to amyloid peptides in APP, which is critical for cell body death and axonal pruning. DR6/TNFRSF21 Protein, Rat (HEK293, Fc) is the recombinant rat-derived DR6/TNFRSF21 protein, expressed by HEK293 , with C-hFc labeled tag.

Rat

DR6/TNFRSF21 protein plays a pivotal role in promoting apoptosis, potentially through a pathway involving the activation of NF-kappa-B. It can also facilitate apoptosis mediated by BAX and the release of cytochrome c from mitochondria into the cytoplasm. This protein is actively involved in neuronal apoptosis, responding to amyloid peptides derived from APP, and is crucial for normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase, releasing sAPP-beta, which binds TNFRSF21, subsequently activating caspases and inducing degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). In addition to its role in neuronal processes, DR6/TNFRSF21 negatively regulates oligodendrocyte survival, maturation, and myelination. Furthermore, it plays a role in T-cell receptor-mediated signaling, adaptive immune responses, and the regulation of T-cell differentiation and proliferation, exhibiting negative regulatory effects on cytokine release and antibody production. Additionally, DR6/TNFRSF21 acts as a regulator of pyroptosis by recruiting CASP8 in response to reactive oxygen species, leading to the activation of GSDMC. It interacts with TRADD, NGFR, CASP8, and N-APP in the intricate network of its molecular functions.

Tumor necrosis factor receptor superfamily member 21; CD358; Tnfrsf21; DR6

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.