protein

EB3/MAPRE3 Protein, Human (His)

HY-P75275

5 μg;10 μg;50 μg

40;70;200 USD

EB3/MAPRE3 Protein, Human (His)

proteins

E. coli

5 μg;10 μg;50 μg

40;70;200 USD

The EB3/MAPRE3 protein is a plus-end tracking protein (+TIP) that dynamically regulates microtubule cytoskeletal dynamics by binding to the plus-end of microtubules. It promotes microtubule growth, stabilizes it at the centrosome, and regulates minus-end microtubule organization. EB3/MAPRE3 Protein, Human (His) is the recombinant human-derived EB3/MAPRE3 protein, expressed by E. coli , with N-His labeled tag.

Human

EB3, a plus-end tracking protein (+TIP), intricately modulates the dynamics of the microtubule cytoskeleton by binding to the plus-end of microtubules. Functionally, EB3 serves as a promoter of microtubule growth and potentially contributes to spindle function by stabilizing microtubules and anchoring them at centrosomes. Additionally, it acts as a crucial regulator of minus-end microtubule organization, participating in the recruitment of CAMSAP2 to the Golgi apparatus through interaction with the complex formed by AKAP9 and PDE4DIP. This interaction is pivotal for tethering non-centrosomal minus-end microtubules to the Golgi, a process essential for polarized cell movement. EB3 forms homodimers and heterodimers with MAPRE1, binding both monomeric and polymerized GTP-bound tubulin. Its intricate network of interactions includes APC2, DCTN1, SRCIN1, CLIP1, SLAIN2, SLAIN1, AKAP9, and PDE4DIP, underscoring its multifaceted role in microtubule dynamics and cellular organization.

Microtubule-associated protein RP/EB family member 3; EBF3; EB3; RP3; MAPRE3

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.