protein

Apolipoprotein A-I/APOA1 Protein, Human

HY-P7526

10 μg;50 μg

107;300 USD

Apolipoprotein A-I/APOA1 Protein, Human

proteins

E. coli

10 μg;50 μg

107;300 USD

406168019

Apolipoprotein A-I/APOA1 Protein is a secreted protein located on the outside of cell membranes and is the main structural apolipoprotein of high-density lipoprotein (HDL), playing a key role in the reverse cholesterol transport pathway. Apolipoprotein A-I/APOA1 protein interacts with the cell surface receptor SR-BI, thereby promoting dengue virus (DV) infection. Apolipoprotein A-I/APOA1 Protein can also activate sperm motility as part of the SPAP complex. Apolipoprotein A-I/APOA1 Protein has anti-inflammatory, anti-atherosclerotic, anti-apoptotic, anti-tumor, and anti-thrombotic functions. Apolipoprotein A-I/APOA1 Protein Protein, Human is made up of 267 amino acids and is expressed in Escherichia coli (E. coli) [1] [2] [3] [4] .

Human

Apolipoprotein A-I/APOA1 Protein is one of the most common proteins in human plasma, typically found in amounts of 100-150 mg/dl, with about 80% produced by the liver and 20% by the intestines [3] . The central region of Apolipoprotein A-I/APOA1 Protein (140-170 aa) is mainly associated with the activation of LCAT, while the C-terminal domain (181-243 aa) plays a key role in lipid binding [3] . Apolipoprotein A-I/APOA1 Protein plays a role in the reverse transport of cholesterol from tissues to the liver for excretion by promoting the flow of cholesterol out of tissues and acting as a cofactor for lecithin-cholesterol acyltransferase (LCAT), effectively protecting the body from the accumulation of cholesterol in tissues [1] . When Apolipoprotein A-I/APOA1 Protein interacts with SRB1, cell adhesion molecules are inhibited. This interaction introduces miRNA223 into endothelial cells, which suppresses the expression of ICAM and VCAM on the endothelial membrane and prevents monocytes from adhering to the endothelial cells, thus having an anti-inflammatory effect [3] . Apolipoprotein A-I/APOA1 protein can bridge DV particles and the cell receptor SR-BI, facilitating the attachment of DV to cells, which leads to viral infection [4] . Apolipoprotein A-I/APOA1 Protein is associated with diseases like viral infections, atherosclerosis, diabetes, neurological disorders, and tumors [3] [4] [5] [6] .

rHuApolipoprotein A-I; ApoA1; Apolipoprotein A-I

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized after extensive dialysis against 20 mM PB, 150 mM NaCl, pH 7.2

Room temperature in continental US; may vary elsewhere.