protein

EphA1 Protein, Mouse (HEK293, His)

HY-P75241

2 μg;10 μg;50 μg;100 μg

35;60;165;280 USD

EphA1 Protein, Mouse (HEK293, His)

proteins

HEK293

2 μg;10 μg;50 μg;100 μg

35;60;165;280 USD

The EphA1 protein is a receptor tyrosine kinase that promiscuously binds to ephrin-A ligands on neighboring cells, initiating contact-dependent bidirectional signaling. The forward signal originates from the receptor and the reverse signal originates from the ephrin ligand. EphA1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived EphA1 protein, expressed by HEK293 , with C-His labeled tag. The total length of EphA1 Protein, Mouse (HEK293, His) is 522 a.a., with molecular weight of ~68 kDa.

Mouse

The EphA1 protein, a receptor tyrosine kinase, engages in promiscuous binding to membrane-bound ephrin-A family ligands on adjacent cells, initiating contact-dependent bidirectional signaling. The downstream pathway originating from the receptor is known as forward signaling, while the pathway downstream of the ephrin ligand is termed reverse signaling. EphA1 exhibits low-affinity binding to EFNA3 and EFNA4 and high-affinity binding to EFNA1, which likely constitutes its cognate/functional ligand. Upon activation by EFNA1, EphA1 induces cell attachment to the extracellular matrix, inhibiting cell spreading and motility through the regulation of ILK and downstream RHOA and RAC. Additionally, EphA1 plays a role in angiogenesis and regulates cell proliferation. It may also be involved in apoptosis processes, contributing to its diverse cellular functions.

Ephrin type-A receptor 1; hEpha1; EPHA1; EPH; EPHT; EPHT1

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.